mycobacterium bovis in humans

However, across the probing questions selected for risk-of-bias assessment, using appropriate sampling frame was not clearly reported from almost half of the studies (Table S2). Biotechnology and Biological Sciences Research Council, Grant/Award Number: BB/L018977/1; Economic & Social Research Council, Grant/Award Number: BB/L018977/1. Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading cause of human deaths due to any infectious disease worldwide. Then, terms within the same concepts were connected with Boolean OR and combined with other components of searching terms using Boolean AND. Tuberculosis (Edinb). The funnel plot (Figure 5) was constructed from study estimates with pseudo 95% confidence limit against standard error of the estimates. Identification of species was primarily based on biochemical tests. Targeted individuals having cattle contact but did not confirm direct link of transmission. The site is secure. Clipboard, Search History, and several other advanced features are temporarily unavailable. The site is secure. Mycobacterium tuberculosis is the leading etiological agent of TB in humans, while M. bovis has a broader host range and is able to infect multiple host species, mainly cattle and including humans, with variable populational persistence . Epidemiology of Mycobacterium bovis Disease in Humans, the Netherlands Treatment of human disease due to Mycobacterium bovis: a systematic All studies that used primarily conventional-based identification methods reported significantly higher prevalence of zoonotic TB than studies that used primarily genotyping-based methods. Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations, Use of DNA amplification for the rapid identification of Mycobacterium bovis, Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. Muller and colleagues projected that the pooled contribution of zoonotic disease in the African region was estimated to be 2.8% of clinically confirmed cases (Mller et al., 2013). Mycobacteria - an overview | ScienceDirect Topics ZoonoticMycobacterium bovis-induced Tuberculosis in Humans. Given that Eggers test indicated as there is a significant small study effect at p-value of p >|t|= 0.000. Although these species can be distinguished by routine genotyping, biochemical characterization and drug susceptibility testing, which generally provide results earlier, have been historically used and can increase the index of suspicion for M. bovis. The double-sided effects of Mycobacterium Bovis bacillus Calmette In recent years, M. bovis infections have been detected sporadically among Nebraska beef herds (late 1990s, 2005, 2009, and 2013) and an elk herd (2009) (Nebraska Department of Agriculture, unpublished data, June 29, 2015). The source population of the relevant disease condition, the third component of the review method, was set as all clinical isolates of the MTBC species identified through either genotyping or phenotyping techniques. Background Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex, causes tuberculosis (TB) in cattle and a wide range of mammals including humans, although to a lesser extent than Mycobacterium tuberculosis. M. tuberculosis is the main causative agent of human TB, and cattle are the primary host of Mycobacterium bovis; due to close interaction between cattle and humans, M. bovis poses a zoonotic risk. All mammalian species,. No persons in this investigation were thought to have had contact with these sources. HHS Vulnerability Disclosure, Help Animal tuberculosis (TB), caused by Mycobacterium bovis, is maintained in Portugal in a multi-host system, with cattle, red deer and wild boar, playing a central role. 2006 Mar;86(2):77-109. doi: 10.1016/j.tube.2005.05.002. Molecular strain typing of Mycobacterium tuberculosis complex in Bamako, Mali. Molecular clustering of patients with diabetes and pulmonary tuberculosis: A systematic review and meta-analysis. Latent infection was diagnosed in six contacts on follow-up examination, 2 months after an initial negative test result (4), for an overall latent infection rate of 25%. Through that, the final searching term (Table S1) was built at PubMed database, which is the primary searching engine. This site needs JavaScript to work properly. Indeed, there are also studies supporting the occurrences of higher prevalence of zoonotic TB among populations that had close contact with animals, farmers and pastoralists (Ameni et al., 2013; Legesse et al., 2011). The evolution of the Multi- and Extensively drug-resistant M. bovis strains (MDR-TB and XDR-TB) represents a global threat to public health. Bovine tuberculosis infection in human historically occurs following consumption of unpasteurised dairy products. This systematic review covered 19 studies published during 10 years from 2009 to 2019. Given that appropriate way of sampling procedures, having clear description of settings and target population, appropriateness and adequacy of subject recruitment, reliability and validity of methods used for the identification of the outcome interest (MTBC species) were emphasized. Mycobacterium bovis induced human tuberculosis in India: Current status Prev Vet Med. However, as there were few molecular studies, we reformulated the review question and searching strategies to identify published articles reported from any country in the world. Taye H, Alemu K, Mihret A, Wood JLN, Shkedy Z, Berg S, Aseffa A (2017). Although zoonotic TB is still reported from most continents in the world, it remains challenging to understand the real impact of the disease because of differences in identification methods. J. et al. Results from sputum-smear microscopy, nucleic acid amplification test, and culture were negative. This can be compared with a prevalence of 8.3% reported from Nigeria by Jenkins et al. Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia. Wedlich N, Figl J, Liebler-Tenorio EM, Khler H, von Pckler K, Rissmann M, Petow S, Barth SA, Reinhold P, Ulrich R, Grode L, Kaufmann SHE, Menge C. Front Vet Sci. Four months later, a U.S.-born Hispanic girl from a nearby town who had been ill for 45 months was also determined to have pulmonary TB caused by M. bovis. The standardization of typing methods, including development of new molecular methods or validation of the existing ones is necessary for proper estimation of the zoonotic TB burden. Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle. Studies reporting TB prevalence data that were published in English during 10 years from 20 April 2009 to 17 April 2019 were identified through search of PubMed and other sources. Unable to load your collection due to an error, Unable to load your delegates due to an error, PRISMA flow diagram shows the searching strategy and screening of eligible studies at different levels of the review process, Findings of a meta-analysis generated from the full model showing the prevalence of, Meta-analysis findings of the random model that shows individual study estimates (ES (95% CI)) of genotyping-based studies and subtotal prevalence of. Molecular typing of Mycobacterium bovis isolates: a review. eCollection 2022. Siala M, Smaoui S, Taktak W, Hachicha S, Ghorbel A, Marouane C, Kammoun S, Gamara D, Slim L, Gdoura R, & Messadi-Akrout F (2017). The BCG human anti-tuberculosis vaccine was developed from MB MB is a part of the Mycobacterium tuberculosis complex and it is hard to distinguish from Mycobacterium tuberculosis itself MB is also difficult to identify and grow in culture, and diagnostic tests rely on specific antigen or DNA gene detection With that in consideration the critical appraisal and quality assessment score, the selected sets of included studies were considered for quantitative analysis. Mycobacterium bovis, one of several mycobacteria of the M. tuberculosis complex, is a global zoonotic pathogen that primarily infects cattle. ** Genotyping results from CDCs National TB Genotyping Service for the isolates from 96 TB patients with culture-confirmed disease in Nebraska during 20062013 indicated that all were M. tuberculosis. PDF Treatment of human disease due to Mycobacterium bovis: a systematic review Ayele WY, Neill SD, Zinsstag J, Weiss MG, & Pavlik I (2004). Epidemiology of Mycobacterium bovis and Mycobacterium tuberculosis in animals: Transmission dynamics and control challenges of zoonotic TB in Ethiopia. Ethiopia, at the Horn of Africa, was represented by five studies (Belay et al., 2014; Firdessa et al., 2013; Gumi et al., 2012; Nuru et al., 2015,2017) followed by Mexico in the Americas with four studies (Blanco-Guillot et al., 2017; Bobadilla-del Valle et al., 2015; Lopez-Rocha et al., 2013; Portillo-Gomez & Sosa-lglesias, 2011). HHS Vulnerability Disclosure, Help In addition, large sequence polymorphism (LSP) typing and IS6110-restriction fragment length polymorphism (RFLP) were also performed in some studies. No information was collected regarding his prior employment in Mexico, but he did report frequent consumption of raw milk. Keywords: Please enable it to take advantage of the complete set of features! Persons with M. bovis infections should be asked about foodborne exposures. MMWR Morb Mortal Wkly Rep 2016;65:197201. To prevent outbreaks of M. bovis in human populations, . Field evaluation of the tuberculin skin test for the detection of Mycobacterium tuberculosis complex infection in communal goats (Capra hircus) in KwaZulu-Natal, South Africa. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. In people, M. bovis causes TB disease that can affect the lungs, lymph nodes, and other parts of the body. NVSL has sequenced 97% of M. bovis isolates from affected U.S. cattle herds since 1997 and 90% from feeder and feedlot cattle (both imported and domestic) since 2000. Before eCollection 2020 Nov. ztrk CE, ahin , ksz , Kl N, Klnel , Aydn L, Atik D, Afin E. Mikrobiyol Bul. Majoor CJ, Magis-Escurra C, van Ingen J, Boeree MJ, van Soolingen D (2011). First-time detection and identification of the Mycobacterium tuberculosis Complex members in extrapulmonary tuberculosis clinical samples in south Tunisia by a single tube tetraplex real-time PCR assay. In 2017, a case of pulmonary TB caused by M. bovis in a human was detected in the Vall d'Hebron Hospital in Barcelona, Spain. He recovered slowly and remained isolated at home until results from sputum smears were negative for AFB in August. You will be subject to the destination website's privacy policy when you follow the link. Frontiers | Whole Genome Sequencing Links Mycobacterium bovis From On the other hand, most of the conventional-based studies, which reported remarkably higher prevalence of M. bovis cases, were highly influenced by their primary objective. Results suggested that the two patients isolates were closely related; phylogenetic comparisons differed by only three single nucleotide polymorphisms (SNPs). CDC. of pages found at these sites. Federal government websites often end in .gov or .mil. Mycobacterium bovis, one of several mycobacteria of the M. tuberculosis complex, is a global zoonotic pathogen that primarily infects cattle. Unauthorized use of these marks is strictly prohibited. Bovine tuberculosis (BTB), caused by Mycobacterium bovis (M. bovis), is an infectious, chronic disease of cattle, which are known to be the primary hosts for this organism [], although the disease has also been reported in different mammalian hosts, including humans [].The disease has high economic relevance within the context of livestock farming; directly affects animal productivity and also . Mycobacterium bovis - an overview | ScienceDirect Topics This person had no affiliation with the church or the school and reported no contact with patient B, who resided in a different town. All three were patient Bs family members who were also potentially exposed to patient A at the church. This is also similar to that of the previous findings reported more than two decades ago in Europe and USA. Regassa Alemayehu, Medhin Girmay, Ameni Gobena (2008). Tracing cross species transmission of Mycobacterium bovis at the Beside methodological differences on species isolation and identification, the proportion of human M. bovis cases reported by primary studies have shown significant variation that could also be due to some underlying conditions. Methods Mycobacterium bovis (15) among 1755 M. tuberculosis complex (MTBC) isolated between 2012 and 2014 were . While two of the facility-based genotyping studies that covered study populations of relatively larger size and who shared some underlying risk factors (such as contact with livestock), reported few human M. bovis cases, suggesting minimal contribution of zoonotic TB (Firdessa et al., 2013; Yeboah-Manu et al., 2016). Tuberculosis(TB) is a chronic communicable bacterial disease caused by Mycobacterium tuberculosis complex (MTBC) species. Inclusion in an NLM database does not imply endorsement of, or agreement with, Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Tuberculosis infection is a condition in which microorganisms [i.e., M. tuberculosis complex] have entered the body and typically have elicited immune responses and includes both latent infection and TB disease. Latent infection is an asymptomatic condition that follows the initial infection; the infection is still present but is dormant (and believed not to be currently progressive or invasive) and might progress to TB disease. [Active] TB disease is determined by finding anatomic changes caused by advancing infection (e.g., shadows from infiltrates on a chest radiograph) or by noting symptoms (e.g., malaise, feverishness, or cough), and typically by both. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5415a2.htm. Before Careers, Unable to load your collection due to an error. Questions or messages regarding errors in formatting should be addressed to Jabbar A, Khan J, Ullah A, Rehman H, & Ali I (2015). Corresponding author: Bryan F. Buss, feu7@cdc.gov, 402-471-8820. Henceforth, in this review, these mixed types of diagnostic procedures were defined as conventional-based identification methods. This review and meta-analysis study has been conducted in accordance with published protocol (ID = CRD42017076409) (Hawult Taye et al., 2017). Persons from countries where both types of infection are prevalent could be infected by either species. In this review, the techniques used in the 19 included studies for identification of the clinical isolates of the MTBC as well as for differentiation of M. bovis from other MTBC species were classified into two groups. Whole-genome sequencing results of the isolates were nearly indistinguishable. Users are referred to the electronic PDF version (https://www.cdc.gov/mmwr) Both groups used selective mycobacterial culture media for cultivation. The https:// ensures that you are connecting to the The latter included molecular techniques such as mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR), spoligotyping and/or any PCR-based amplification methods using specific primers. Bidovec-Stojkovic U, Zolnir-Dovc M, Supply P (2011). For instance, three of the genotyping studies that reported relatively higher numbers of M. bovis cases targeted very few selected high-risk individuals (Ereqat et al., 2012; Jenkins et al., 2011; Nuru et al., 2017). The .gov means its official. Mycobacterium bovis, a member of theMycobacterium tuberculosis complex, is an important cause ofdisease in cattle, but it can also cause disease in humans [1]. All HTML versions of MMWR articles are generated from final proofs through an automated process. Ghariani A, Jaouadi T, Smaoui S, Mehiri E, Marouane C, Kammoun S, Essalah L, Driss M, Messadi F, Slim-Saidi L (2015). The chapters are organized for quick access to well-indexed topics, and extensive reference lists are included to aid infectious disease specialists . This work was funded by the Biotechnology and Biological Sciences Research Council, the Department for International Development, the Economic & Social Research Council, the Medical Research Council, the Natural Environment Research Council and the Defence Science & Technology Laboratory, under the Zoonoses and Emerging Livestock Systems (ZELS) programme, ref: BB/L018977/1. Vet Immunol Immunopathol. The https:// ensures that you are connecting to the M. bovis primarily causes disease in cattle but also infects deer and other mammals (1). Bryan F. Buss, DVM1,2; Alison Keyser-Metobo, MPH2; Julie Rother3; Laura Holtz4; Kristin Gall, MSN2; John Jereb, MD5; Caitlin N. Murphy, PhD6; Peter C. Iwen, PhD6,7; Suelee Robbe-Austerman, DVM8; Melissa A. Holcomb, DVM2; Pat Infield2 (View author affiliations). In addition, publication bias and precision of study estimates were examined visually from the funnel plots and statistically tested using Eggers test. Two of the authors (HT and SB) independently performed data extraction using piloted and structured data extraction form. Characteristics of included studies (a) that used genotyping techniques and (b) studies which primarily focused on conventional dentification techniques to report the prevalence Mycobacterium bovis identified from the total detected MTBC species. Christianson S, Wolfe J, Orr P, Karlowsky J, Levett PN, Horsman GB, Thibert L, Tang P, Sharma MK (2010). Hence, all of those studies were excluded at this level and they were not considered in the remaining quantitative meta-analysis estimates. Not only in resource-limited countries, until the end of the 20th century, investigations of zoonotic TB in many of the developed countries were mainly based on phenotypic characteristics of the species such as colony morphology and use of biochemical tests (Sreevatsan et al., 1996). Further clarification for unclear scores and additional information was sought to solve discrepancies between the two reviewers. However, infection of Mycobacterium bovis, primarily an animal pathogen, also leads to the development of 'human tuberculosis'.Infected animals have been considered the major source of M. bovis infection and humans get exposed to M. bovis through close contact . Then, further subgroup analysis was done from 14 of the genotyping-based studies to estimate individual study findings and subtotal ES (prevalence of M. bovis) based on specific characteristics. Diagnosis of lymph node tuberculosis using the GeneXpert MTB/RIF in Tunisia, International Journal of Mycobacteriology. The overall estimate of human M. bovis infection, which was generated from the first random model with all included studies, showed a pooled prevalence of 12.1% [ES (95% CI) of 0.121 (0.095, 0.148)]. Human tuberculosis caused by Mycobacterium bovis: a retrospective comparison with Mycobacterium tuberculosis in a Mexican tertiary care centre, 20002015. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The persistence of M. bovis in cattle internationally and the failure to pasteurize dairy products in many locations means that further infections in humans should be anticipated. Characteristics of included studies and their main findings were summarized in tables and discussed with narrative syntheses. In spite of the above methodological differences, the pooled prevalence (1.4%) of M. bovis aggregated from genotyping-based studies was comparable with estimates previously reported in the global systematic review by Muller et al (Mller et al., 2013). Mycobacterium bovis (M. bovis) is another mycobacterium that can cause TB disease in people. Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies. Whole-genome sequencing can be used to identify species and investigate transmission. Journal of Epidemiology and Community Health. M. bovis may have transitioned from humans to animals; animal domestication facilitated spread and maintenance in animals [ 2 ], although the strains are remarkably related genetically (99.95 percent) [ 3 ]. Epub 2022 Sep 13. Preliminary investigation of the transmission of tuberculosis between farmers and their cattle in smallholder farms in northwestern Ethiopia: a cross-sectional study. 2020 Nov 30;14(11):e0008894. Among patient Bs five siblings, four were born in the United States, had never traveled abroad, and did not recall consuming dairy products from Mexico; three of these four siblings were infected. Airborne person-to-person transmission has been suspected but is difficult to confirm. Despite control efforts, Mycobacterium bovis incidence among cattle remains high in parts of England, Wales, and Northern Ireland, attracting political and public health interest in potential spread from animals to humans. government site. Future investigations on zoonotic TB should carefully consider these differences when evaluating prevalence results. Genetic characterization of Mycobacterium tuberculosis in the West Bank, Palestinian Territories. Polyresistant Mycobacterium bovis Infection in Human and Sympatric Molecular epidemiology and whole genome sequencing analysis of - PLOS Second, dietary history details could be forgotten during the interim, or consumers might be unaware of the origin or pasteurization status of dairy products they consumed. Findings from the contact investigations suggest possible airborne transmission, because approximately one third of the infections could not be explained by potential exposure in countries where M. tuberculosis complex infections are common. Potentially exposed health care workers were notified for follow-up at their respective facilities with a request to report infections to the health department if identified. Particularly, some population groups who have close contact with infected animals could be at higher risk than the general population (Alemayehu et al., 2008; Gumi et al., 2012; de la Rua-Domenech, 2006). Characteristics of included studies and their main findings were summarized in tables and discussed with narrative syntheses. Nevertheless, the highest prevalence of M. bovis was documented from studies conducted in two African countries, Ethiopia and Nigeria (Jenkins et al., 2011; Nuru et al., 2017), while two of the largest studies with very low individual estimates of zoonotic TB did have an influence on the pooled (subtotal) African prevalence (Firdessa et al., 2013; Yeboah-Manu et al., 2016). Human tuberculosis caused by Mycobacterium bovis: a retrospective Federal government websites often end in .gov or .mil. GeneXpert assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens from a high TB endemic area of Pakistan. Kidane D, Olobo JO, Habte A, Negesse Y, Aseffa A, Abate G, Yassin MA, Bereda K, & Harboe M (2002). Evaluation of 24 locus MIRU-VNTR genotyping of Mycobacterium tuberculosis isolates in Canada. BOVIS. Bethesda, MD 20894, Web Policies Among 77 persons for whom retesting was indicated, 56 (73%) were retested, and six (11%) were determined to have latent infection (Table 2). [Investigation of Mycobacterium bovis subsp. In fact, only five of the genotyping-based studies (Firdessa et al., 2013; Gumi et al., 2012; Jenkins et al., 2011; Nuru et al., 2015,2017) and one study that relied on biochemical test identification techniques (Portillo-Gomez & Sosa-lglesias, 2011) had clearly described supplementation of pyruvate or glycerol to enhance growth of M. bovis on the culture medium (Table 1a). National Library of Medicine Chest radiography was consistent with advanced TB with cavities; numerous AFB were reported from sputum-smear microscopy. M. tuberculosis is the main causative agent of human TB, and cattle are the primary host of Mycobacterium bovis; due to close interaction between cattle and humans, M. bovis poses a zoonotic risk. SR15). Influenced by primary objective that was intended to show performance of GeneXpert that does not differentiate. Belay M, Ameni G, Bjune G, Couvin D, Rastogi N, Abebe F (2014). The result from nucleic acid amplification testing of sputum was positive for M. tuberculosis complex. Mycobacterium bovis is a slow-growing (16- to 20-hour generation time) aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB ). They differed in methodology for subsequent identification using either phenotypic or genotypic typing methods, or both. Therefore, statistical estimates (ES; 95% CI) generated from the following three meta-analysis models represented findings of the genotyping-based studies only. During the church contact investigation, she and her parents were determined to have latent infection, but they had stopped taking rifampin after only 2 months. Among 100 church members (excluding patient B and high-priority contacts of either patient), 28 (28%) had latent infection, including five U.S.-born children. Quality of studies and risk of bias were assessed using standard tools for prevalence study reports. Initially, the protocol was restricted to include studies conducted in developing countries only. That can be used to obtain the individual study weights. Contact investigation for cases of pulmonary, Nebenzahl-Guimaraes H, Verhagen LM, Borgdorff MW, van Soolingen D. Transmission and progression to disease of. The overall pooled prevalence of M. bovis aggregated from all included studies was 12.1% of the total MTBC isolates, while the corresponding pooled figure from the 14 genotyping-based studies was only 1.4%. 1Armauer Hansen Research Institute, Addis Ababa, Ethiopia, 2Department of Epidemiology and Biostatistics, University of Gondar, Gondar, Ethiopia, 4Department of Veterinary Medicine, University of Cambridge, Cambridge, UK, 3Biostatistics and bioinformatics, University of Hasselt, Hasselt, Belgium, 5Bacteriology Department, Animal and Plant Health Agency, Weybridge, UK.
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