diabetes research edinburgh scotland

In addition to touring the University of Edinburgh research facilities at the Western General Campus, the group also learned about the vital . scheme. Diabetes research (Edinburgh, Scotland) Publications The influence of insulin and sorbinil on myo-inositol uptake in peripheral nerve from normal and diabetic rats and a neuroblastoma cell line. Therefore, data were not missing completely at random (MCAR) and were either MAR or not missing at random (NMAR). Endocrinology is the study of hormones. S2 Fig. Journal | Diabetes Research (edinburgh, Scotland) - Scilit Among the group were some of the charity's most passionate and dedicated fundraisers. Jans A, Nslund I, Ottosson J, Szabo E, Nslund E, Stenberg E. PLoS Med. The mean (SD) HbA1c at follow-up was 63.0 (15.5) mmol/mol in the intervention group and 67.8 (14.7) mmol/mol in the usual care group. Passionate about what we do, we put lived experience of diabetes at the heart of everything we do. Findings: 0.3% (n=845) of those with diabetes had developed severe or fatal COVID-19, representing rate ratios of 3.86 (2.74, 5.45) in type 1 and 1.69 (1.56, 1.84) in type 2 diabetes. Diabetes research (Edinburgh, Scotland) | Read 823 articles with impact on ResearchGate, the professional network for scientists. Methods A cohort of 1849411 individuals aged <35 years without diabetes, including all those in Scotland who subsequently tested positive for SARS-CoV-2, was followed from 1 March 2020 to 22 November 2021. Coronavirus Disease 2019;DiRECT, Median body mass index (BMI) at diagnosis was 32.3 kg/m2. Edinburgh actively contributes to the study programme of the Scottish Diabetes Research Network (SDRN). Oral presentation at the 31, Colombo M, McGurnaghan S, Bell S, Palmer C, MacKenzie F, Chalmers J, Collier A, Green F, Lindsay RS, Macrury S, McKnight JA, Patrick AW, Pearson DW, Petrie J, Thekkepat S, McKeigue P, Colhoun HM on behalf of the SDRNT1BIO investigators. Socio-economic differences in cardiovascular disease risk factor prevalence in people with type 2 diabetes in Scotland: a cross-sectional study. -, Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Odds of missing data in people with type 2 diabetes in Scotland diagnosed 30 years of age who had at least 1 HbA1c 48 mmol/mol (6.5%) after diagnosis of diabetes and who were alive and had at least 1 HbA1c recorded in 2019. People with a previous history of bariatric surgery had higher odds of remission compared with people with no previous history (OR 11.93 (95% 9.41 to 15.13) P < 0.001) (Fig 3). University homepage go back to the start and try again, Schools and departments list browse all areas of the University, Freedom of information publication scheme, There may be a typing mistake in the address bar. The population was identified from The Scottish Care Information-Diabetes (SCI-Diabetes) registry, which is a population-level diabetes registry derived from NHS primary and secondary care data. Similarities between our findings and Karter and colleagues were that remission of type 2 diabetes was more common in people aged 65 years, people who were not prescribed GLT at diagnosis of diabetes, and people who had a lower HbA1c at diagnosis. We defined remission as all HbA1c values <48 mmol/mol in the absence of glucose-lowering therapy (GLT) for a continuous duration of 365 days before the date of the last recorded HbA1c in 2019. However, more data are needed to establish whether a very low calorie diet approach will be effective or appropriate in people that have been excluded from trials. The Scottish Diabetes Research Network (SDRN) is a clinical research network commissioned in 2006 by the Chief Scientist Office of the Scottish Government to coordinate and facilitate diabetes research across Scotland. body mass index;CI, We are delighted to have been awarded these research funds from Diabetes UK. glucose-lowering therapy;ICD-10, From this population, we selected people who were aged 30 years who were diagnosed with type 2 diabetes between January 1, 2004 (when registration to SCI-Diabetes was near complete across Scotland) and December 31, 2018 [2]. For full functionality of this site, please enable JavaScript. This highlights the need for a definitive and comprehensive consensus on the definition of type 2 diabetes remission that is clear for people with type 2 diabetes and healthcare professionals in all settings [8]. Estimating prevalence of type 2 diabetes remission is needed to inform allocation of resources and creation of new clinical pathways to support this group of people to stay in remission. Having established that remission is possible using nonsurgical interventions, future trials could now broaden their inclusion criteria to explore the effectiveness of interventions in a more representative sample of the type 2 diabetes population. Published: 1 January 1994. Our Staff | NHS Research Scotland | NHS Research Scotland The most common endocrine disorder is diabetes (diabetes mellitus) which results from a deficiency of the hormone insulin. I have read the journals policy and the authors of this manuscript have the following competing interests: BK is national lead for diabetes and chair of the Scottish Diabetes Group which sits directly within the Clinical Priorities team at Scottish Government, member of the Type 2 Diabetes Prevention Oversight group which is a Scottish Government related group, speciality adviser to Chief Medical Officer for diabetes and endocrine. The Look Action for Health in Diabetes (AHEAD) trial among overweight and obese United States adults with type 2 diabetes found that, of the participants who attained remission of type 2 diabetes, a third of the group that received an intensive lifestyle intervention, and 40% to 50% of the control group returned to type 2 diabetes status each year [10]. 215199) and in Scotland (no. Learn more about volunteering for us. Learn more about the past, present and future of diabetes research in Scotland. e1003828. Our cohort consisted of 162,316 individuals, all of whom had at least 1 HbA1c 48 mmol/mol (6.5%) at or after diagnosis of diabetes and at least 1 HbA1c recorded in 2019 (78.5% of the eligible population). Poster presentation at the 51, Looker H, Livingstone S, McGurnaghan S, Collier A, Green F, Lindsay RS, MacRury S, McKnight JA, Milburn K, Palmer CAN, Patrick AW, Pearson DWM, Pearson ER, Petrie JR, Thekkepat S, Walker J, Colhoun HM, on behalf of the SDRNT1BIO investigators. Continuous covariates at diagnosis were defined as the median of all values recorded within a 90-day window around diagnosis (HbA1c at diagnosis; BMI at diagnosis; and weight at diagnosis). Relation of Incident Type 1 Diabetes to Recent COVID-19 Infection Edinburgh. All associations persisted after excluding people with severe comorbidity commonly associated with weight loss at diagnosis of diabetes, including people who may have been mistakenly assigned to the bariatric surgery group who were obese but whose indication for gastrectomy was for stomach cancer rather than obesity. Previous history of bariatric surgery also had a strong association with diabetes remission; however, bariatric surgery was rare in the study cohort (488 people), while there were almost 31,000 people with no history of GLT prescription. Diabetes research (Edinburgh, Scotland) | fatcat! What is Endocrinology? Bookshelf Factors associated with remission were older age (odds ratio [OR] 1.48 [95% CI 1.34 to 1.62] P < 0.001) for people aged 75 years compared to 45 to 54 year group), HbA1c <48 mmol/mol at diagnosis (OR 1.31 [95% CI 1.24 to 1.39] P < 0.001) compared to 48 to 52 mmol/mol), no previous history of GLT (OR 14.6 [95% CI 13.7 to 15.5] P < 0.001), weight loss from diagnosis to 2019 (OR 4.45 [95% CI 3.89 to 5.10] P < 0.001) for 15 kg of weight loss compared to 0 to 4.9 kg weight gain), and previous bariatric surgery (OR 11.9 [95% CI 9.41 to 15.1] P < 0.001). The incidence of diabetes in the anti-asialo GM1 antibody . You can go back to this later in your, Opens a new window for Diabetes UK on facebook, Opens a new window for Diabetes UK on Twitter, Opens a new window for Diabetes UK on youtube, Opens a new window for Diabetes UK on instagram, Emotional wellbeing and diabetes: A way forward (PDF, 515KB), Newly diagnosed with Type 2 education pack, Impact of our work on people living with diabetes - Diabetes Scotland annual report - 2016, (PDF, 1.54MB), Making Connections - supporting young people with Type 1 (PDF, 1MB). CI, confidence interval; OR, odds ratio. World Health Organization. No significant differences were identified between groups in weight, treatment pattern, adherence to medication, or quality of life in secondary analyses. L Bent-Hansen . We carried out a cross-sectional study estimating the prevalence of remission of type 2 dia- betes in all adults in Scotland aged 30 years diagnosed with type 2 diabetes and alive on December 31, 2019. Our findings highlight that there is no differentiation between intentional and nonintentional weight loss in current definitions of remission, and people who attain remission by unintentional weight loss caused by severe illness could still be defined as being in remission of type 2 diabetes [4,8]. Our vision is to create a world where diabetes can do no harm, and with more and more people affected by diabetes, we continue to fight harder than ever before. Share This article was published on 1 Apr, 2021 The current research projects in 2017-18 are: The Study is managed under a supported collaboration model and includes researchers from a wide range of institutes: Collaborating laboratories that are carrying out biomarker measurements on SDRNT1BIO samples include: Interested collaborators should contact the Study Coordinator in the first instance, emailSDRNT1BIO@ed.ac.uk. 26 June 2023. Type of diabetes in SCI-Diabetes is validated for research purposes using an algorithm combining clinical coding, treatment, and age of onset [2,19]. Socioeconomic status was defined using the 2016 Scottish Index of Multiple Deprivation (SIMD). Poster presentation at the 77, Bermingham ML, Colombo M, McGurnaghan S, Blackbourn L, Vukovi F, Pui Bakovi M, Lauc G, Agakov FA, Agakov AS, Hayward C, Klaric L, McKeigue PM, Colhoun HM, SDRNT1BIO investigators. doi: 10.15277/bjd.2019.221 2-hr PG, Guidelines are required for management and follow-up of this group and may differ depending on whether weight loss and remission of diabetes were intentional or unintentional. 29 June, 2023 14:43. Recognised body which has been Polymorphisms in ST3GAL4, ST6GAL1, PHIP, FUT8 are associated with variation within the serum N-glycome of Scottish type 1 diabetes patients. Remission of type 2 diabetes was assessed between January 1, 2019 and December 31, 2019. Our cohort consisted of 162,316 individuals, all of whom had at least 1 HbA1c 48 mmol/mol (6.5%) at or after diagnosis of diabetes and at least 1 HbA1c recorded in 2019 (78.5% of the eligible population). In this study, we found that 4.8% of people with type 2 diabetes who had at least 1 HbA1c 48 mmol/mol (6.5%) after diagnosis of diabetes and had at least 1 HbA1c recorded in 2019 had evidence of type 2 diabetes remission. Biomarkers associated with progression of renal disease in type 1 diabetes. Poster presentation at the 53, Colombo M, Valo E, McGurnaghan S, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM, on behalf of the SDRNT1BIO and Finndiane Investigators. Cohort profile: the Scottish Diabetes Research Network national Shareen Forbes (MBChB, PhD, FRCP) | The University of Edinburgh S2 Table. Our results suggest that supporting clinicians to discuss remission and to refer to weight management services with early or diet-controlled diabetes is a rational approach. Stephanie.Read@ed.ac.uk. Prevalence of remission of type 2 diabetes among people with type 2 diabetes in Scotland who had at least 1 HbA1c 48 mmol/mol (6.5%) after diagnosis of diabetes and had at least 1 HbA1c recorded in 2019 stratified by age group and change in weight from diagnosis to 2019. Hormones are chemicals which are produced by a variety of glands and travel in the circulation (blood stream) to exert their effects, often upon a range of different organ systems. Edinburgh. For secondary analyses, adjusted mean ambulatory systolic blood pressure was 3.06 mmHg lower (95% CI 0.565.56 mmHg,p= 0.017) and mean ambulatory diastolic blood pressure was 2.17 mmHg lower (95% CI 0.623.72,p= 0.006) among people in the intervention group when compared with usual care after adjustment for baseline differences and minimization strata. The current research projects in 2017-18 are: Glycaemia Trajectories in Type 1 Diabetes and their Association with Complications (Diabetes UK funded) Harnessing genetic information in the SDRNT1BIO to understand Type 1 diabetes and its complications (Diabetes UK funded) Extreme Phenotypes Relevant to Diabetic Complications in Type 1 Diabetes .
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