Manage Settings The combination of this monoclonal antibody with bendamustine is highly effective. Thrombosis is a serious condition and may occur in the blood vessels of your: Blood clots can also form in the veins of your legs. This is watchful waiting. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information. At the same time, your bone marrow continues to fill up with abnormal cells. Medical Videos Privacy Policy, Images and Text Policy Editorial Policy, Information Policy Advertising Policy, Financial Disclosure Policy Cookie Policy, About Us Contact Us. Macroglobulinemia is suspected in patients with symptoms of hyperviscosity or other typical symptoms, particularly if anemia is present. Waldenstrom macroglobulinemia (WM, Lymphoplasmacytic lymphoma) is a rare slow-growing cancer that affects your blood cells. If you would like to change your settings or withdraw consent at any time, the link to do so is in our privacy policy accessible from our home page.. A partial volume exchange transfusion is sometimes still done in some cases. If you have this genetic fault, doctors will be able to confirm you have PV. Alexander Turchin et al. Oza A, Rajkumar SV: Waldenstrom macroglobulinemia: Prognosis and management. Waldenstrom macroglobulinemia typically affects people aged 65 and older. If polycythaemia vera is suspected, and/or the person is experiencing symptoms of hyperviscosity, refer urgently to a haematologist for treatment. Available from. Comprehensive information for people with cancer, families, and caregivers, from the American Society of Clinical Oncology (ASCO), the voice of the world's oncology professionals. Reiss UM, Bensimhon P, Zimmerman SA, Ware RE. Manifestations may include hyperviscosity, bleeding, recurrent infections, generalized adenopathy, and hepatosplenomegaly. Retinal fluorescein angiography can also be used to demonstrate hyperviscosity. The baby will be monitored for complications of hyperviscosity. Men are affected more often than women. 2007 Jan-Feb;15(1):31-4. doi: 10.1097/01.crd.0000214959.82120.97. Hyperviscosity syndrome results from the presence of serum proteins with high intrinsic viscosity. National Library of Medicine People with a history of serious bone conditions are also at risk for developing this condition. If the patient has not been diagnosed with an underlying pathologic process that could have caused the HVS (eg, multiple myeloma, Waldenstrm macroglobulinemia, hyperproliferative blood cell. 1999 Aug;7(38):82-4. If cold agglutinins are present, the direct Coombs test usually is positive. This test is called a hematocrit. National Organization for Rare Disorders. Polycythemia can result from conditions that develop before birth. As stated above, Hyperviscosity Syndrome affects mostly infants and young children but it has the potential to be present even through the adult ages of the child but this depends on whether the child received appropriate treatment and care during childhood for Hyperviscosity Syndrome. Irregular bleeding, such as bleeding gums or chronic nosebleeds. A tingling sensation in your fingers and toes. Sometimes blood vessels tear, causing your nose, gums or the retinas in your eyes to seep (ooze) blood. hyperviscous h-pr-vi-sks adjective The diagnosis of hyperviscosity syndrome is clinical and requires the presence of symptoms and a compatible underlying disorder. The Adult Patient with Eisenmenger Syndrome: A Medical Update after Management | Polycythaemia/erythrocytosis - CKS | NICE Nosebleeds: Hyperviscosity or unusually thick blood may cause nosebleeds and bleeding gums. Symptomatic hyperviscosity is a well-established phenomenon in Waldenstrm macroglobulinemia (WM). ; Referral is also indicated for people testing negative for the JAK2 V617F mutation, with other features suggestive of a myeloproliferative disease, such as high platelets and/or white count, enlarged spleen, family history of myeloproliferative . Plasma viscosity is measured to confirm suspected hyperviscosity. 1. ++Waldenstrm's Macroglobulinemia: An Exploration into the Pathology and Diagnosis of a Complex B-Cell Malignancy++. Corticosteroids, fludarabine, rituximab, proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide, lenalidomide, and pomalidomide), Bruton's tyrosine kinase inhibitors (ibrutinib, acalabrutinib, and zanubrutinib), idelalisib, everolimus, or the combination of ibrutinib and rituximab may be helpful; other alkylating drugs can be used for palliation. Hyperviscosity syndrome is most common in patients with Waldenstrm macroglobulinemia (10% to 30%), leukemia, and multiple myeloma. You may not have any symptoms at all before or when youre diagnosed. These irregular blood cells clog and congest the body. Marked engorgement and localized narrowing of retinal veins, which resemble sausage links, suggest a hyperviscosity syndrome. Primary sites of disease include peripheral blood, bone marrow read more or other lymphoproliferative disorders. Investigating the power of music for dementia. This article may contains scientific references. If theres no clear cause for your polycythaemia and you dont have the JAK2 genetic fault, your doctor will do more tests to confirm a diagnosis. Moderate normocytic, normochromic anemia, marked rouleau formation, and a very high erythrocyte sedimentation rate (ESR) may occur. Providers cant cure this condition, but they do have treatments that ease and sometime eliminate its symptoms. Providers have also identified risk factors that may increase the chance of developing Waldenstrom macroglobulinemia. This can cause encephalopathy, a disease affecting the brain. Seizures. Nucleoside analogs (fludarabine and 2-chlorodeoxyadenosine) produce responses in large numbers of newly diagnosed patients but have been associated with a high risk of myelodysplasia and myeloid leukemia. A less common complication of PV is gout, which can cause inflammation of the joints. In WM, abnormal cells stay in your bone marrow, where they keep multiplying and do not die. (2008). If Hyperviscosity Syndrome is caused due to conditions like leukemia then treatment for that condition is to be done first for symptoms of Hyperviscosity Syndrome to come down. A company limited by guarantee 738089 (registered in England and Wales). (Healthcare providers may refer to this condition by the initials WM or the name lymphoplasmacytic lymphoma). Use for phrases Hyperviscosity Syndrome develops when there is abundant red blood cells in the blood. Data regarding the predictors of sym Researchers are investigating what triggers the changes. Hyperviscosity Syndrome: Causes, Symptoms, and Diagnosis - Healthline Often, patients require no treatment for many years (1) Treatment references Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. People with MM who experience mental confusion symptoms such as headache, brain fog, and loss of vision should contact a doctor. Treasure Island (FL): StatPearls Publishing; 2021. The risk of clots is highest if the PV isnt treated. Symptoms of high blood viscosity include spontaneous bleeding from mucous membranes, visual disturbances due to retinopathy, and neurologic symptoms ranging from headache and vertigo to seizures and coma . When the CXCR4 gene mutates, it makes proteins that help the abnormal cells in Waldenstrom macroglobulinemia continue to multiply. Encephalopathy alters brain function or structure, and it can cause mental confusion. Bone marrow studies show a variable increase in plasma cells, lymphocytes, plasmacytoid lymphocytes, and mast cells. Additionally, because MM can weaken the bones in the body, if this affects the bones of the spine, they may collapse and press on the spinal nerves. Blood viscosity depends on many factors: red blood cell mass and morphology, aggregation and dispersion of blood cells, plasma viscosity, temperature and shear stress [ 2 - 4 ]. The trusted provider of medical information since 1899, Monoclonal Gammopathy of Undetermined Significance (MGUS). In children and newborns, hyperviscosity is more often due to polycythemia, therefore arterial or venous hematocrit should be measured. is among the first to achieve this important distinction for online health information and services. Cold sensitivity, Raynaud syndrome Raynaud Syndrome Raynaud syndrome is vasospasm of parts of the hand in response to cold or emotional stress, causing reversible discomfort and color changes (pallor, cyanosis, erythema, or a combination) in read more , or recurring bacterial infections may occur. When these genes mutate, they turn a single normal B-cell into an abnormal cell that reproduces more cells. Use OR to account for alternate terms Genetic and Rare Diseases Information Center. When they accumulate in the blood in high levels, the blood can become viscous or thick. People with kidney disease may experience mental confusion. The predominant symptoms of HVS are mucocutaneous bleeding, ophthalmologic, and neurologic ( Table 1 ). Manifestations may include hyperviscosity, bleeding, recurrent infections read more . The clinical presentation in HVS consists principally of the triad of mucosal bleeding, visual changes, and neurologic symptoms. Hear a word and type it out. Bethesda, MD 20894, Web Policies Unauthorized use of these marks is strictly prohibited. The consent submitted will only be used for data processing originating from this website. Disclaimer. In rare cases, hyperviscosity may cause stroke-like symptoms. Learn more about the MSD Manuals and our commitment to Global Medical Knowledge. Learn more about these factors here. Thesecan be reversed byplasmapheresis.1 This is hyperviscosity syndrome. People with Waldenstrom macroglobulinemia may experience the following symptoms or signs. Polycythemia - newborn: MedlinePlus Medical Encyclopedia They can join up with other proteins, causing blockages in the pipes, and eventually kidney failure. However, during the first several months, IgM levels may increase, requiring plasma exchange. Polycythemia in neonates is a venous hematocrit 65%. Polycythaemia vera (PV) symptoms and diagnosis | Blood Cancer UK Kaseb H, Gonzalez-Mosquera LF, Parsi M, Mewawalla,P. Immunoglobulin M (IgM) proteins are large molecules. They have Acquired Immunodeficiency Syndrome, They have monoclonal gammopathy of undetermined significance, They have biological family members who have WM or who have other kinds of. A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). However, there is little evidence that this is effective. o [teenager OR adolescent ], , MD, Institute for Myeloma and Bone Cancer Research, (See also Overview of Plasma Cell Disorders Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically read more .). Updated by: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. . Most published studies of polycythemia use spun hematocrits, which are no longer routinely done and are generally higher than those done on automated counters. These can include slurred speech and weakness on one side of the body. Because platelets help the blood clot, people with this condition may experience serious bleeding from small cuts or scratches. Lanzkowsky's Manual of Pediatric Hematology and Oncology. Although an elevated serum viscosity supports the diagnosis, it does not fully correlate with the severity of disease; when serum viscosity is less than 3 cP, hyperviscosity is excluded. These can build up in the blood, which makes it thicker than normal. Eventually, abnormal cells outnumber normal cells. Parents should contact their health care provider if they think their child shows signs of delayed development. Polycythemia. An important and dreadful feature of hyperviscosity is overt thrombosis in organ systems, resulting in cerebrovascular accident and myocardial infarction. All rights reserved. Although initially, an individual may have no symptoms, they can appear over time. If you are concerned about any changes you experience, please talk with your doctor. Our articles are resourced from reputable online pages. Hyperviscosity is a clinical syndrome involving sludging of blood within vessels and sometimes thrombosis. sleep apnoea (where your normal breathing is disrupted whileyoure asleep). Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada) dedicated to using leading-edge science to save and improve lives around the world. Symptoms and signs include thirst, lethargy, dry mucosa, decreased urine output, and, as the degree read more causing relative hemoconcentration and an elevated hematocrit mimics polycythemia, but red blood cell mass is not increased. red cell mass studies (using radioisotopes) to distinguish apparent polycythaemia from actual polycythaemia. Am J Cardiol. In infants, it can happen due to certain conditions that develop during the growing stages of the fetus or during childbirth. Treat with IV hydration and sometimes partial exchange transfusion. Pillai AA, Fazal S, Babiker HM. The thickened blood doesnt flow easily through your bodys tiny blood vessels. Last reviewed by a Cleveland Clinic medical professional on 06/06/2022. Common manifestations include lytic lesions in bones that cause read more ) as well as measurement of cryoglobulins, rheumatoid factor, and cold agglutinins; coagulation studies; and a direct antiglobulin (Coombs) test. Manifestations may include hyperviscosity, bleeding, recurrent infections read more ). This may lead to tissue death from lack of oxygen. Learn more about multiple myeloma, how it affects the body, and the. URAC's accreditation program is an independent audit to verify that A.D.A.M. Castillo JJ, Allan JN, Siddiqi T, et al. Polycythemia can occur when there are too many red blood cells (RBCs) in an infant's blood. Youd then have a set of tests to confirm the exact diagnosis of PV. Cleveland Clinic is a non-profit academic medical center. Waldenstrom macroglobulinemia is a rare slow-growing cancer that affects your blood cells. These can include slurred speech and weakness on one side of the body. It affects some people with MM. Hydroxyurea therapy for management of secondary erythrocytosis in cyanotic congenital heart disease. Hyperviscosity Syndrome The relative viscosity of serum is normally 14-1 8 times that of water. Hyperviscosity syndrome (HVS) refers to the clinical sequelae of increased blood viscosity. Fluids may be given through the vein. Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada) dedicated to using leading-edge science to save and improve lives around the world. People experiencing unpleasant treatment side effects should contact a doctor. Some of the symptoms of Hyperviscosity Syndrome are: Benefits of HRM Headaches Seizures Reddish skin The baby will be abnormally sleepy The baby will not feed properly There will be visual disturbances. The use of emergency apheresis in the management of plasma cell Living with Waldenstrom macroglobulinemia differs depending on your situation. Hyperviscocity: Treatment, Symptoms, and Causes - WebMD Epub 2007 Oct 5. Polycythaemia vera (PV) treatment and side effects. Hyperviscosity syndrome. Frontiers | Hyperviscosity Syndrome in Paraprotein Secreting Conditions Presentation Acute hyperviscosity syndrome is characterized by elevated serum immunoglobulins that increase blood viscosity and decrease tissue perfusion. ST changes improve after conservative, MeSH The MYD88 protein serves as communications central for proteins inside and outside immune cells. We follow a strict editorial policy and we have a zero-tolerance policy regarding any level of plagiarism. To use the sharing features on this page, please enable JavaScript. Introduction Hyperviscosity syndrome (HVS) is an oncologic emergency that classically presents with the triad of neurological deficits, visual changes, and mucosal bleeding. They were exposed to certain solvents, dyes and pesticides. Rosenkrantz TS, Stonestreet BS, Hansen NB, et al. People with PV are at an increased risk of thrombosis (blood clots). In some cases this may be fatal. o [ abdominal pain pediatric ] Signs and symptoms of congestive heart failure (CHF) from . Heres what may happen then: Left untreated, WM can be life-threatening. Immunofixation electrophoresis of concentrated urine frequently shows a monoclonal light chain (more often kappa []), but gross Bence Jones proteinuria is unusual. Good results are also possible in infants who receive treatment for severe hyperviscosity. Hyperviscosity Syndrome|Causes|Symptoms|Treatment|Survival Rate Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. Providers cant cure this condition, but they do have treatments that ease and sometimes eliminate its symptoms. Ann Intern Med. [ 4] Constitutional symptoms and. Get useful, helpful and relevant health + wellness information. Ankylosing Spondylitis Pain: Fact or Fiction. People with MM may feel mental confusion symptoms to different degrees. The slower blood flow decreases blood flow to the brain, causing mental confusion and dizziness. In some people with MM, the abnormal myeloma proteins damage the kidneys. Bone weakness may also occur if an individual has plasmacytoma. Immediate therapy of symptomatic hyperviscosity is directed at reduction of blood viscosity by plasmapheresis to control symptoms. Bone problems can include bone pain and bone weakness. Tashi T, Prchal JT. Clots can also form in the vessels in your abdomen (stomach area). Diagnosis of hyperviscosity syndrome is clinical. Pol Merkur Lekarski. 2. Symptoms and signs of hyperviscosity syndrome are those of heart failure, thrombosis (cerebral and renal vessels), and central nervous system dysfunction, including tachypnea, respiratory distress, cyanosis, plethora, apnea, lethargy, irritability, hypotonia, tremulousness, seizures, and feeding problems. Over a period of 8 years, he was treated with multiple chemotherapeutic regimens with response and subsequent relapse. Connective tissue disorders. o [ pediatric abdominal pain ] Normal immunoglobulins are decreased in half of the patients. Difficulty walking. When treatment is necessary, it varies according to the patient. Ameans that a person has not experienced B symptoms, listed below. What is Leukocytosis: Causes, Symptoms, Treatment, Diagnosis, Dietary Dos and Donts for Migraine Sufferers, Shirshasana (Headstand) Versus Inversion Therapy Using Inversion Table, Understanding Joint Pain and Tips to Get Relief Using Home Remedies, Erectile Dysfunction: Does Opioid Cause ED, Libido: Opioid Induced Female Sexual Dysfunction, Urinalysis to check the levels of glucose, blood, and protein in the urine, BUN to see if the protein is breaking down adequately or not, Creatinine levels to check the function of the kidneys. Hyperviscosity Syndrome - an overview | ScienceDirect Topics The trusted provider of medical information since 1899, Perinatal Polycythemia and Hyperviscosity Syndrome, Polycythemia is an abnormal increase in red blood cell mass, defined in neonates as a venous hematocrit. For example, the electrolyte imbalance associated with kidney problems can cause delirium. Examination may disclose lymphadenopathy, hepatosplenomegaly, and purpura (which rarely can be the first manifestation). Acalabrutinib and zanubrutinib cause less toxicity than ibrutinib. Blood Is Thicker: Hyperviscosity Syndrome - The American Journal of Clipboard, Search History, and several other advanced features are temporarily unavailable. Talk to your healthcare provider about your situation. Waldenstrom macroglobulinemia starts in white blood cells called B-lymphocytes or B-cells that are under development in your bone marrow. The result of these tests alone arent enough for your doctor to diagnose PV, as there are a number of other reasons and conditions that can mean you have too many red blood cells. Learn more about the MSD Manuals and our commitment to Global Medical Knowledge. Use for phrases If the levels are abnormally increased then it may point decisively towards Hyperviscosity Syndrome. All rights reserved. (See also Liver Structure and Function and Neonatal read more .). Hyperviscosity syndrome due to high levels of paraprotein is a serious, and potentially life-threatening, clinical complication most commonly observed in patients with WM. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. This helps to rule out any other bone marrow problems. o [ abdominal pain pediatric ] People with anemia may have weakness, dizziness, and shortness of breath. The most commonly used replacement fluid is 4%-5% human albumin in physiol Is the ketogenic diet right for autoimmune conditions? It can cause mental confusion in some people. Oncologic Emergencies: Recognition and Initial Management | AAFP See also Perinatal Problems. Waldenstrom macroglobulinemia usually affects people 65 and older, causing symptoms like fatigue that some people may dismiss as simply signs theyre growing old. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. There may be blockages due to abundance of RBCs, proteins, or WBCs in the blood. Because white blood cells protect the body from harmful germs, someone with leukopenia has a lower resistance to infections. There have been some cases where some children with Hyperviscosity Syndrome tend to develop certain neurological problems later on in life as a result of inadequate amount of oxygen being delivered to the brain. Increased serum viscosity usually results from increased circulating serum immunoglobulins and can be seen in such diseases as Waldenstrm macroglobulinemia and multiple myeloma. Doctors use a three-step staging system to classify the severity of multiple, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Kidney disease is relatively common in people with MM. Hyperviscosity Syndrome - Medscape The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Hyperviscosity is generally associated with impaired tissue perfusion and oxygen delivery, which causes symptoms such as headache, visual disturbance, loss of concentration, paresthesia, muscle . Sludging occurs because increased red blood cell mass causes a relative decrease in plasma volume and a relative increase in proteins and platelets. If youre concerned you may be at risk, ask your healthcare provider to evaluate your situation so you know what to expect. Prematurity is defined by the gestational age at which infants are born. Clinical manifestations of macroglobulinemia include bleeding, recurrent infections, generalized adenopathy, and hepatosplenomegaly. Laboratory evaluation includes tests used to evaluate plasma cell disorders (see Multiple Myeloma Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The mutation involves the MYD88 gene. See this image and copyright information in PMC. Hyperviscosity syndrome causes, symptoms, diagnosis, treatment & prognosis Fortunately, healthcare providers have treatments to ease and possibly eliminate Waldenstrom macroglobulinemia symptoms. In: Lanzkowsky P, Lipton JM, Fish JD, eds. MNT is the registered trade mark of Healthline Media. Rituximab can reduce tumor burden without suppressing normal hematopoiesis. In some cases, treatments may eliminate WM symptoms for months or years. Initially, a person with MM may have no symptoms. WM happens when genetic mutations change certain blood cells. Your doctor may refer to this as your packed cell volume (or PCV). Age, family history, gender and a pre-existing condition are all risk factors that may increase the chance someone will develop Waldenstrom macroglobulinemia. MM treatments can affect the body and brain. 2005-2023 American Society of Clinical Oncology (ASCO). People who do have symptoms may experience fatigue and bone pain, which are two common signs of the condition. Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. Hearing problems. official website and that any information you provide is encrypted The physician may also do other tests like. Find out more about bone marrow biopsies. If a clot dislodges and travels to the lung, it may cause a pulmonary embolism (or PE). Symptoms and signs include thirst, lethargy, dry mucosa, decreased urine output, and, as the degree read more ). https://www.ncbi.nlm.nih.gov/books/NBK526081/, Rose SS, Shah AA, Hoover DR, Saidi P. Cyanotic congenital heart disease (CCHD) with symptomatic erythrocytosis. WM happens when genetic mutations change certain blood cells, setting up a chain reaction of medical conditions that may be life-threatening. Does multiple myeloma cause mental confusion? - Medical News Today Kotby AA, Mamdouh NM, Eissa DS, Ahmed NT. Yes, mental confusion can be a sign of MM. Less commonly, patients develop hyperviscosity due to the large amounts of high molecular weight monoclonal IgM proteins circulating in plasma, but most patients do not develop problems related to high IgM levels. StatPearls. For additional information visit Linking to and Using Content from MedlinePlus. Partial exchange is done by removing blood in aliquots of 5 mL/kg and immediately replacing it with an equal volume of 0.9% saline. Some of the symptoms of Hyperviscosity Syndrome are: In case if the pediatrician suspects that the infant may have Hyperviscosity Syndrome then the physician will order blood tests to look at the levels of the red blood cells in the blood. Excessive amounts of IgM M-proteins (monoclonal immunoglobulin protein, which may consist of both heavy and light chains or of only one type of chain) can also accumulate in other disorders, causing manifestations similar to macroglobulinemia. Incidence of polycythemia is about 3 to 4% (range 0.4 to 12%), and about half of infants with polycythemia have hyperviscosity. Cancer.Net GuideWaldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma). Use to remove results with certain terms Is mental confusion a sign of multiple myeloma? Multiple myeloma - Symptoms - NHS De Sousa, A. This is known as hyperviscosity and may mean you get some of these symptoms: headaches; confusion; blurred vision; skin reddening (plethora) itchy skin (pruritus). Use the menu to choose a different section to read in this guide. Polycythemia. Headache is common, and dizziness, vertigo, and . The link you have selected will take you to a third-party website. Hyperviscosity Syndrome Treatment & Management - Medscape Keywords: One study reported about half of people with MM has some degree of kidney problems. Learn more about the MSD Manuals and our commitment to. Retinal hemorrhages, exudates, microaneurysms, and papilledema occur in late stages. Do serum protein electrophoresis followed by serum and urine immunofixation, and quantitative immunoglobulin levels. Nelson Textbook of Pediatrics. Symptoms of hyperviscosity. Symptoms and Causes What are the symptoms of hyperviscosity syndrome? In rare cases, hyperviscosity may cause stroke-like symptoms. Hyperviscosity syndrome - Wikipedia